| item | description | category | filter | more on... |
| SPE | Saw Palmetto Extract | Misc/Food |
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| SPE | Semiconductor Product Equipment | Business/Products |
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| SPE | Sepulot, Sabah, Malaysia | Regional/Airport Codes |
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| SPE | Serial Parallel Expansion | IT/Hardware |
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| SPE | Serum Protein Electrophoresis | Medical/Laboratory |
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| SPE | Service Processing Element | IT/Networking |
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| SPE | Service Procurement Engineering | Governmental/US Gov. |
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| SPE | Slightly Pointed East | Edu./Geology |
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| SPE | Society of Petroleum Engineers | Edu./Geology |
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| SPE | Software Port Entity | IT/Software |
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| SPE | Solid Phase Extraction | Edu./Physics |
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| SPE | Solid Polymer Electrolysis | Governmental/NASA |
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| SPE | Sony Pictures Entertainment | Business/Firms |
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| SPE | Southern Pipeline Extension | Other/Transportation |
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| SPE | Special Police Establishment | Governmental/FBI |
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| SPE | Special Purpose Entity | IT/General |
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| SPE | Static Phase Error | Governmental/NASA |
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| SPE | Surface Preparation Equipment | IT/Hardware |
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| SPE | Synchronous Payload Envelope | IT/Telecom |
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| SPE | System Processing Engine | IT/Software |
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